Description:

Antibodies against the Sm antigens of the small nuclear ribonucleoproteins (snRNPs) are a very specific marker for the diagnosis of systemic lupus erythematosus (SLE). Antibodies against the Sm proteins are found in 20-30% of SLE patients. Anti-Sm antibodies are observed at a high titer in the active period of SLE and at a low titer in the non-active period. Antibodies directed against Sm proteins as well as DNA found in sera from patients with SLE have been included as one of the American College of Rheumatology classification criteria for SLE. Sm antigen is now known to be consisted of at least nine different polypeptides. Anti-Sm antibodies are predominantly directed against the SmD1 protein of the snRNP complex.

Signosis 是一家专业的生物分析供应商，致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年，坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究，基于自有专利技术，开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区，客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司