Description:

Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients of Polymyositis (PM) and Dermatomyositis (DM). PM and DM are idiopathic inflammatory myopathies, characterized by proximal muscle weakness, elevated muscle enzyme activities and electromyographic and histological feature. This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis. Anti-Jo-1 antibody is predominantly found in 20-30% of PM patients and 60-70% of PM with interstitial pulmonary fibrosis. The antibody is also found in DM, although less frequently than in PM. , It is rare in children with PM or DM and in other connective tissue diseases. Moreover, the serum levels of anti-Jo-1 antibody strongly correlate with disease activity representing a good marker for disease monitoring.

Signosis 是一家专业的生物分析供应商，致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年，坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究，基于自有专利技术，开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区，客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司