细胞裂解物中Signosis/Human HIF调节的cDNA图谱/AP-3102/1 Ea
商品编号：
AP-3102
品牌：
signosisinc
市场价：
¥9780.00
美元价：
5868.00
产品分类：
转录表达
公司分类：
Target_Expression
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:
Rapidlygrowingtumorsresultinhypoxicregions.Adaptiveresponsesofmostcellstohypoxiaare(1)toproduceVEGFandotherhypoxia-inducedangiogeniccytokinesthatpromoteincreasedtissuevascularization,therebyincreasingtissueoxygenation,and(2)toswitchmetabolicallyfromoxidativephosphorylationtoanaerobicglycolysis.Hypoxia-inducIBLefactor1(HIF-1)isanoxygen-regulatedtranscriptionalactivatorthatplaysessentialrolesintheprocess.TheHIF-1alphasubunitisoxygen-dependentubiquitinationandproteasomaldegradation.Inaddition,cytokinesincludinginterleukin-1(IL-1)andtumornecrosisfactor-alpha(TNF-alpha)stimulateHIF-1dependentgeneexpression.HIF-1increasestheexpressionofseveralgenesthatpromotebloodflowandinflammation,suchasvascularendothelialgrowthfactor(VEGF). TogetabetteroverviewofgeneexpressionofHIF-1 regulatedgenes,SignosishasdevelopedaCDNAPlateArraywhichcouplesitsCLTM cDNAsynthesiskitwhichallowsreversetranscriptiondirectlyfromcelllysateswithoutRNApreparation.Thisplate-basedassaysallowsprofilingtheexpressionof20+HIF-1-regulatedgenesdirectlyincelllysates.Thisassayprovidesquantitativedata,allowingresearcherstoscreenmultiplesamples,aswellashighsensitivity,allowingresearcherstouselesssample.ApplicableGrid:
ListofApplicableGenes
| BCL2 | HIF-2a | PDGF-A | BCL2 | HIF-2a | PDGF-A | BCL2 | HIF-2a | PDGF-A | BCL2 | HIF-2a | PDGF-A |
| Beta-actin | HPRT | PDK1 | Beta-actin | HPRT | PDK1 | Beta-actin | HPRT | PDK1 | Beta-actin | HPRT | PDK1 |
| CA9 | IGF-II | NDRG1 | CA9 | IGF-II | NDRG1 | CA9 | IGF-II | NDRG1 | CA9 | IGF-II | NDRG1 |
| CTSD | Leptin | SAG | CTSD | Leptin | SAG | CTSD | Leptin | SAG | CTSD | Leptin | SAG |
| BHLHB2 | MMP1 | SLC6A8 | BHLHB2 | MMP1 | SLC6A8 | BHLHB2 | MMP1 | SLC6A8 | BHLHB2 | MMP1 | SLC6A8 |
| Glut-1 | MXI-1 | VEGF | Glut-1 | MXI-1 | VEGF | Glut-1 | MXI-1 | VEGF | Glut-1 | MXI-1 | VEGF |
| Glut-3 | NDRG2 | VHL | Glut-3 | NDRG2 | VHL | Glut-3 | NDRG2 | VHL | Glut-3 | NDRG2 | VHL |
| HIF-1a | PAI-1 | Blank | HIF-1a | PAI-1 | Blank | HIF-1a | PAI-1 | Blank | HIF-1a | PAI-1 | Blank |
品牌介绍
Signosis 是一家专业的生物分析供应商，致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年，坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究，基于自有专利技术，开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区，客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司
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