Description:

Adipocytokines are a group of diverse effector molecules that are produced by adipose cells. Abnormal expression of adipokines such as Resistin is associated with the development of insulin resistance, diabetes and other metabolic and cardiovascular disorders in man. Mouse Resistin was described as a novel obesity-mediated adipocytokine that impairs glucose homeostasis by affecting both insulin-stimulated glucose uptake in adipose tissue and hepatic glucose production during fasting. However, there were initially two opposite views on human Resistin. Some studies have shown the ccorrelations between Resistin and obesity. Serum Resistin levels increase with increased adiposity and conversely, decline with decreased adiposity following medical treatment. However, other studies presented contradictory evidences that significantly decreased serum concentrations of resistin with increased adiposity. Resistin has also been shown to increase the expression of several pro-inflammatory cytokines including IL-1, IL-6, IL-12, and TNF-a via NF-kB.

Signosis 是一家专业的生物分析供应商，致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年，坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究，基于自有专利技术，开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区，客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司