Description:

The Unfolded Protein Response (UPR) is a conserved and essential stress response that cells activate to combat endoplasmic reticulum (ER) stress, commonly caused by the accumulation of misfolded proteins or failing protein quality control.   UPR signaling has been identified as one of the avenues leading to the inflammatory response. The integration of ER stress, oxidative stress and the inflammatory response is critical to the pathogenesis of a variety of diseases, such as  diabetes, Alzheimer’s, Parkinson’s, and obesity.  It has been demonstrated that some cytokines can activate ER Stress and that ER stress can increase the expression of certain cytokines as well.  Therefore, cytokine profiling provides a valuable tool for examining the relationship between cytokine expression and ER stress response.  Signosis’ ER stress ELISA Strip allows quantitative profiling and measures 8 ER stress-associated cytokines. The list of cytokines is as follows: TNFα, IL-1β,IFNγ, IL-6 ,IGF-1, MCP-1, Leptin and TGFβ .

Signosis 是一家专业的生物分析供应商，致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年，坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究，基于自有专利技术，开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区，客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司