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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > Signosis/ATF6 ELISA Kit (Chemiluminescence)/TE-0042/1 Ea
商品详细Signosis/ATF6 ELISA Kit (Chemiluminescence)/TE-0042/1 Ea
Signosis/ATF6 ELISA Kit (Chemiluminescence)/TE-0042/1 Ea
Signosis/ATF6 ELISA Kit (Chemiluminescence)/TE-0042/1 Ea
商品编号: TE-0042
品牌: signosisinc
市场价: ¥12160.00
美元价: 7296.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Description:

ER stress (UPR) response is governed by three transmembrane sensors: PERK, IRE1 and ATF6.  These stress sensors control a complex ER-to-nucleus signaling pathway that transmits information across the ER membrane to an extensive gene-expression program.  Two major transcription factors for UPR are ATF4 and ATF6.  Both ATF4 and ATF6 belong to a basic leucine zipper ATF/CREB family, but have distinct functions UPR.  ATF6 is a type II transmembrane ER protein that is activated by proteolytic cleavage.  Active ATF6 translocates to the nucleus where it forms active homodimers or dimerizes with NF-Y and XBP1s and binds to promoter regions containing ATF/cAMP response elements (CREs) and/or ER Stress Elements (ERSE).  ATF4 belongs to PERK-eIF2-ATF4 axis and regulates the expression of genes involved in amino acid biosynthesis and transport functions, antioxidant stress responses, and apoptosis.  ATF4 induces both pro-survival (early) and pro-apoptotic (late) transcriptional programs. Prolonged or extreme ER stress uses ATF4 to upregulate proapoptotic protein C/EBP homologous protein (CHOP).  To distinguish the function of ATF4 and ATF6 in ER stress, Signosis has developed ATF4 /ATF6 ELISA kit for detecting and comparing ATF4 and ATF6 DNA binding activities for human, mouse and rat samples.
品牌介绍
Signosis 是一家专业的生物分析供应商,致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年,坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究,基于自有专利技术,开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区,客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司