Description:

Stat3 (signal transducer and activator of transcription 3) promotes cell survival/proliferation, motility and immune tolerance and is considered as an oncogene. When signaled by cytokines and growth factors, such as oncostate, the activated Stat3 is translocated into the nucleus, where the gene expression is regulated by binding to the DNA recognition site. Signosis has developed a Stat3 ELISA kit to detect Stat3 activation. STAT1 exerts a wide spectrum of functions on both tumor cells and the immune system.  Stat1 is usually considered as a tumor suppressor by enhancing  inflammation and triggering anti-proliferative and pro-apoptotic responses in tumor cells. Upon activated by cytokines, such as INFgamma, stat1 forms homodimers or heterodimers with Stat3 or Stat2 and binds to the response element on the promoter region of target genes. Signosis has developed a Stat1 ELISA kit to monitor Stat1 activation.
 
While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is considered as an oncogene, STAT1 enhances inflammation and innate and adaptive immunity, triggering in most instances anti-proliferative and pro-apoptotic responses in tumor cells. Despite being activated by common cytokines and growth factor receptor pathways, their activation is reciprocally regulated to redirect and balance cytokine/growth factor signals from proliferative to apoptotic, or from inflammatory to anti-inflammatory. Signosis has developed Stat3/Stat1 ELISA kit to distinguish the activation of  Stat3 and Stat1.

Signosis 是一家专业的生物分析供应商，致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年，坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究，基于自有专利技术，开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区，客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司