Description:

Stat3(signaltransducerandactivatoroftranscription3)promotescellsurvival/proliferation,motilityandimmunetoleranceandisconsideredasanoncogene.Whensignaledbycytokinesandgrowthfactors,suchasoncostate,theactivatedStat3istranslocatedintothenucleus,wherethegeneexpressionisregulatedbybindingtotheDNArecognitionsite.SignosishasdevelopedaStat3ELISAkittodetectStat3activation.STAT1exertsawidespectrumoffunctionsonbothtumorcellsandtheimmunesystem. Stat1isusuallyconsideredasatumorsuppressorbyenhancing inflammationandtriggeringanti-proliferativeandpro-apoptoticresponsesintumorcells.Uponactivatedbycytokines,suchasINFgamma,stat1formshomodimersorheterodimerswithStat3orStat2andbindstotheresponseelementonthepromoterregionoftargetgenes.SignosishasdevelopedaStat1ELISAkittomonitorStat1activation.
 
WhileSTAT3promotescellsurvival/proliferation,motilityandimmunetoleranceandisconsideredasanoncogene,STAT1enhancesinflammationandinnateandadaptiveimmunity,triggeringinmostinstancesanti-proliferativeandpro-apoptoticresponsesintumorcells.Despitebeingactivatedbycommoncytokinesandgrowthfactorreceptorpathways,theiractivationisreciprocallyregulatedtoredirectandbalancecytokine/growthfactorsignalsfromproliferativetoapoptotic,orfrominflammatorytoanti-inflammatory.SignosishasdevelopedStat3/Stat1ELISAkittodistinguishtheactivationof Stat3andStat1.

Signosis 是一家专业的生物分析供应商，致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年，坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究，基于自有专利技术，开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区，客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司