
Signosis/SATB1 ELISA试剂盒(比色法)/TE-0008/1 Ea
商品编号:
TE-0008
品牌:
signosisinc
市场价:
¥12160.00
美元价:
7296.00
产品分类:
夹心法ELISA
公司分类:
Sandwich_method_ELISA
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description:
SATB1isanuclearproteinwhichplaysacrucialroleinmetastasisofbreastcancer.Itpromotestumorgrowthandmetastasisbychangingtheexpressionofhundredsofgenes,affectingcelladhesion,cellsignaling,cell-cycleregulation,andotherfunctions,includingtheepidermalgrowthfactorgeneHer2.SATB1isnotexpressedinallcells.OnlythemetastaticcellsexpressSATB1,andthemostaggressivebreastcancercellsshowthehighestlevelsoftheprotein.WhenSATB1isdetectedinabreasttumor,thecancerishighlylikelytoprogressorrecur.StudieswithhumanprimarybreastcancertissuesamplesindicatedthatthehighestlevelsofSATB1wereinsamplesfrompatientswhosesurvivaltimeshadbeenshortest;patientswhosetumorsampleshadnoSATB1expressiongenerallyhadlongersurvivaltimes.Inaddition,SATB1"sABIlitytoregulategeneexpressionwasidentifiedascriticaltoT-celldevelopment.StudiesrevealedthatSATB1interactswithHDAC1orPCAF,andisregulatedbyphosphorylationandcleavedbyCaspase6.TheexpressionishighinJurkatandlowinHeLacells. SignosisoffersSATB1ELISAkittofacilitatethemeasurementofthisimportantproteinincancermetastasis.ApplicableGrid:
ELISAKitsAvailable:
SATB1ELISAKit(Colorimetric)TE-0008 |
SATB1ELISAKit (Chemiluminescence)TE-0022 |
Principle:
TFELISAkitishighsensitiveandspecificassaywithasimpleandoptimizedprocedure.The96-well(8X12strip)clearplateispre-immobilizedwiththeTFconsensussequencingoligo.TheactivatedTFinnuclearextractorthewholecelllysateisaddedinthewellandbindstotheoligo.TheactivatedTFisdetectedwithaspecificantibodyagainstthesubunitandaHRPconjugatedsecondaryantibody.Theassayutilizescolorimetricdetectionmethod,whichcanbeeasilymeasuredbyspectrophotometry.
Data:
品牌介绍
Signosis 是一家专业的生物分析供应商,致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年,坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究,基于自有专利技术,开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区,客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司
联络我们