
带核提取试剂盒/FA-1008-NE/1 Ea的Signosis/胆固醇代谢TF活化分析板阵列
商品编号:
FA-1008-NE
品牌:
signosisinc
市场价:
¥15300.00
美元价:
9180.00
产品分类:
基因突变
公司分类:
Genetic_mutations
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description:
CholesterolisanessentialcomponentofcellmembranestoensurecellviABIlityandcellgrowth,andalsoservesasaprecursorforsteroidsandbileacids.ThechangesincholesterollevelcouldleadtoabnormalBIOLOGicalprocess.Theelevatedlevelshavebeenreportedtobeassociatedwithseveraldiseases,includingcardiovasculardisease,heartattack,strokeandHuntington"sdisease.Ithasbeenwidelyreportedthatcholesterolhomeostasisandmetabolismareregulatedbyagroupoftranscriptionfactors.TheSREBP-2transcriptionfactor,forinstance,isresponsIBLeforregulatingcholesterolsynthesisintheliver.LXR,ontheotherhand,servestomonitorcholesterollevelsandinteractswithoxysterolstodrivethedisposalofexcesscholesterol.FXRdetectsintracellularlevelsofbileacidsandworkstopreventtheirover-accumulation.Profilingtheregulationandactivationpatternsoftheseassociatedtranscriptionfactorsiscrucialtofurtherunderstandingandunravelingtheintricatecholesterolmetabolismpathway.ApplicableGrid:
ListofApplicableTFs:
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | |
A | SREBP | PPAR | SREBP | PPAR | SREBP | PPAR | SREBP | PPAR | SREBP | PPAR | SREBP | PPAR |
B | LXR | Coup-TF | LXR | Coup-TF | LXR | Coup-TF | LXR | Coup-TF | LXR | Coup-TF | LXR | Coup-TF |
C | FXR | NUR77 | FXR | NUR77 | FXR | NUR77 | FXR | NUR77 | FXR | NUR77 | FXR | NUR77 |
D | ATF4 | EGR | ATF4 | EGR | ATF4 | EGR | ATF4 | EGR | ATF4 | EGR | ATF4 | EGR |
E | CREB | GATA | CREB | GATA | CREB | GATA | CREB | GATA | CREB | GATA | CREB | GATA |
F | FOXO | NFkB | FOXO | NFkB | FOXO | NFkB | FOXO | NFkB | FOXO | NFkB | FOXO | NFkB |
G | HNF | CHOP | HNF | CHOP | HNF | CHOP | HNF | CHOP | HNF | CHOP | HNF | CHOP |
H | C/EBP | Blank | C/EBP | Blank | C/EBP | Blank | C/EBP | Blank | C/EBP | Blank | C/EBP | Blank |
品牌介绍
Signosis 是一家专业的生物分析供应商,致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年,坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究,基于自有专利技术,开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区,客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司
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