Description:

TranscriptionalregulationplaysacriticalroleinthecontrolofBIOLOGicalprocesses,andtranscriptionfactorshavebeenconsideredasmasterswitchesforcellfatedetermination.ThecancerstemcellparADIgmpostulatesthatdecontrolledtissue-specificstemcellsorProgenitorcellsareprecursorsforcancerbiogenesis.Cancerstemcellsareasubsetofcancercellswithinatumorthathavestemcell-likecharacteristics.DuringtumOrigenesis,deregulatedtranscriptionfactorexpressionoractivationcanpromoteabnormalself-renewal,proliferation,anddifferentiationofthecells.Forexample,OCT4,Sox2,KLF4,MycandNanoghavebeenshowntopossessthepowertoreprogramsomaticcellsintopluripotentcellsbyreactivatingpluripotentgenesandsilencingsomaticgenes.Understandingtheactivationpatternsofcancerstemcellrelatedtranscriptionfactorsinatumorcanhelptounderstandthetranscriptionalmechanismofcancerstemcellandprovidebetterapproachesfortargetingandeliminatingcancerstemcells.

ApplicableGrid:

ListofApplicableTFs:

1

2

3

4

5

6

7

8

9

10

11

12

A

Androgen

KLF4

Snail

Androgen

KLF4

Snail

Androgen

KLF4

Snail

Androgen

KLF4

Snail

B

AP1(Jun)

Myc

SOX2

AP1(Jun)

Myc

SOX2

AP1(Jun)

Myc

SOX2

AP1(Jun)

Myc

SOX2

C

AP2

Nanog

SOX9

AP2

Nanog

SOX9

AP2

Nanog

SOX9

AP2

Nanog

SOX9

D

CREB

NFkB1

STAT3

CREB

NFkB1

STAT3

CREB

NFkB1

STAT3

CREB

NFkB1

STAT3

E

ER

NKX3.1

TBX3

ER

NKX3.1

TBX3

ER

NKX3.1

TBX3

ER

NKX3.1

TBX3

F

FoxO3

Oct-3/4

Twist-1

FoxO3

Oct-3/4

Twist-1

FoxO3

Oct-3/4

Twist-1

FoxO3

Oct-3/4

Twist-1

G

Gli

p53

WT1

Gli

p53

WT1

Gli

p53

WT1

Gli

p53

WT1

H

HIF-1

PRDM14

Blank

HIF-1

PRDM14

Blank

HIF-1

PRDM14

Blank

HIF-1

PRDM14

Blank

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