Signosis/Rat HIF-regulated cDNA Plate Array/AP-1121/1 Ea
商品编号:
AP-1121
品牌:
signosisinc
市场价:
¥10480.00
美元价:
6288.00
产品分类:
转录表达
公司分类:
Target_Expression
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description:
Rapidlygrowingtumorsresultinhypoxicregions.Adaptiveresponsesofmostcellstohypoxiaare(1)toproduceVEGFandotherhypoxia-inducedangiogeniccytokinesthatpromoteincreasedtissuevascularization,therebyincreasingtissueoxygenation,and(2)toswitchmetabolicallyfromoxidativephosphorylationtoanaerobicglycolysis.Hypoxia-inducIBLefactor1(HIF-1)isanoxygen-regulatedtranscriptionalactivatorthatplaysessentialrolesintheprocess.TheHIF-1alphasubunitisoxygen-dependentubiquitinationandproteasomaldegradation.Inaddition,cytokinesincludinginterleukin-1(IL-1)andtumornecrosisfactor-alpha(TNF-alpha)stimulateHIF-1dependentgeneexpression.HIF-1increasestheexpressionofseveralgenesthatpromotebloodflowandinflammation,suchasvascularendothelialgrowthfactor(VEGF).ApplicableGrid:
ListofApplicableGenes
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | |
A | ANGPTL4 | Glut-3 | PDGF-A | ANGPTL4 | Glut-3 | PDGF-A | ANGPTL4 | Glut-3 | PDGF-A | ANGPTL4 | Glut-3 | PDGF-A |
B | 18SrRNA | HIF-1a | PDK1 | 18SrRNA | HIF-1a | PDK1 | 18SrRNA | HIF-1a | PDK1 | 18SrRNA | HIF-1a | PDK1 |
C | BCL2 | HIF-2a | RTP | BCL2 | HIF-2a | RTP | BCL2 | HIF-2a | RTP | BCL2 | HIF-2a | RTP |
D | CREBP | HPRT | SAG | CREBP | HPRT | SAG | CREBP | HPRT | SAG | CREBP | HPRT | SAG |
E | CTSD | IGF-II | UCP3 | CTSD | IGF-II | UCP3 | CTSD | IGF-II | UCP3 | CTSD | IGF-II | UCP3 |
F | EP300 | Leptin | VEGF | EP300 | Leptin | VEGF | EP300 | Leptin | VEGF | EP300 | Leptin | VEGF |
G | EPO | MMP2 | VHL | EPO | MMP2 | VHL | EPO | MMP2 | VHL | EPO | MMP2 | VHL |
H | Glut-1 | PAI-1 | Blank | Glut-1 | PAI-1 | Blank | Glut-1 | PAI-1 | Blank | Glut-1 | PAI-1 | Blank |
品牌介绍
Signosis 是一家专业的生物分析供应商,致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年,坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究,基于自有专利技术,开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区,客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司
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