Description:

Smad transcription factors lie at the center of the transforming growth factor-beta (TGF-β) pathway, which is one of the most important cytokine signaling pathways. Members of the transforming growth factor-beta (TGF-β) superfamily bind to serine/threonine kinase receptors and specifically activate intracellular Smad proteins. Smads 2 and 3 are activated by activin/nodal and TGF-β, whereas Smads 1, 5 and 8 are activated by TGF-β-like BMP (Bone morphogenetic proteins). Smads family can be subsequently classified based on their activation by TGF-β or BMP cytokine family. These activated Smads form the complexes with co-Smads, translocate from cytoplasm into nucleus and bind to the distinctive consensus binding sequences on the target promoter region to regulate the transcription of genes. Signosis has developed the Smad2/3 ELISA kit for the analysis of TGF-β/Smad pathway, Smad1/5/8 ELISA kit for the analysis of BMP/Smad pathway, and a combined kit (48 wells for Smad2/3 and 48 wells for Smad1/5/8) to facilitate studying activation of different Smad-related pathways.

Signosis 是一家专业的生物分析供应商，致力于基于微孔板分析技术的生命科学研究产品的开发、生产和销售。Signosis 成立于2007年，坐落于世界研发中心--美国硅谷的中心地带。公司专注于细胞因子、转录因子、miRNA及疾病标志物等重要调控因子和标志物的研究，基于自有专利技术，开发完成400多种先进而独特的用于发现、筛选和分析的生命科学研究产品。Signosis 产品销售遍布北美、欧洲、亚洲及中东等主要国家和地区，客户涵盖美国国立卫生研究院、哈佛大学、耶鲁大学等著名研究机构以及众多制药公司